January 23, 2019
April 16, 2021
In this Euroanesthesia #EA18 lecture Annika Reintam (Tartu, Estonia) discusses the Pathophysiological mechanisms and consequences of gut edema
Pathophysiological mechanisms and consequences of gut edema
Annika Reintam Blaser, MD, PhD (email@example.com)
Tartu, Estonia and Lucerne Switzerland
Gut edema in acute illness is not yet sufficiently studied and existing knowledge is largely based on experimental animal studies or small studies in healthy volunteers. However, increasing evidence confirms that gut edema impairs intestinal motility and healing of bowel anastomoses, being therefore an important contributor to outcome.
Current presentation focuses mainly on the role of fluids in development of intestinal edema.
The magnitude of the edema seems to depend on
Edema activates similar pathways as mechanical stretch of the bowel. An experimental study in rats showed that activation of signaling pathways to intestinal edema is very similar to 2-hour application of mechanical longitudinal distension of the bowel to 122.5% from its original length. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875413/
Such cell stretch with altered cytoskeleton explains bowel dysmotility and impaired healing of anastomoses related to gut edema, but is also a possible explanation for systemic effects leading to inflammation and multiple organ failure via damaged gut barrier integrity.
Importantly, effect of edema on bowel motility may be comparable to the effect of peritonitis or endotoxemia. https://www.ncbi.nlm.nih.gov/pubmed/29251668
Crystalloids leave intravascular space and reach interstitial space fast. Colloids stay longer in circulation, but then also partially enter interstitial space. In general, fluids with longer elimination half-time also stay longer in the interstitial space. Intestinal interstitium normally has a low compliance, transferring fluids fast into lymphatics. Lymphatic flow is responsible for bringing interstitial albumin or other colloid molecules back into the circulation.
In patients with increased mesenteric venous pressure (caused by right heart failure, mesenteric hypervolemia for other reasons or increased intra-abdominal pressure), interstitial pressure raises and intestinal interstitial space may become a space with high compliance. https://www.ncbi.nlm.nih.gov/pubmed/23747781
Lymphatic flow is then impaired due to compression via an increased pressure in interstitial space, and impaired gut motility (mesenteric lymph vessels are valve-less and lymphatic flow is therefore dependent on bowel movements). https://www.physiology.org/doi/10.1152/ajpgi.1988.254.3.G389
In summary, development, magnitude and persistence of gut edema is tightly related to fluid management. The body seems to interpret gut edema in a similar way as a mechanical stretch. Gut edema itself has dramatic effects on bowel motility, which may even be comparable to ongoing peritonitis.
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